CENPH Full-Length MS Protein Standard


Product Description:

Name CENPH Full-Length MS Protein Standard
Cat# CPFL304531
Protein Namecentromere protein H
SymbolCENPH
SynonymsNNF1; PMF1;PMF1; NNF1, MIND kinetochore complex component, homolog; kinetochore protein CENP-H; centromere protein H
AccessionNM_022909
Cytogenetic5p15.2
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW28.3 kDa
Expression TrueORF CloneRC204531
DescriptionCENPH Full-Length MS Protein Standard (NP_075060), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Centromere and kinetochore proteins play a critical role in centromere structure, kinetochore formation, and sister chromatid separation. The protein encoded by this gene colocalizes with inner kinetochore plate proteins CENP-A and CENP-C in both interphase and metaphase. It localizes outside of centromeric heterochromatin, where CENP-B is localized, and inside the kinetochore corona, where CENP-E is localized during prometaphase. It is thought that this protein can bind to itself, as well as to CENP-A, CENP-B or CENP-C. Multimers of the protein localize constitutively to the inner kinetochore plate and play an important role in the organization and function of the active centromere-kinetochore complex.

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