| Name | TGM1 Full-Length MS Protein Standard |
|---|---|
| Cat# | CPFL304492 |
| Protein Name | transglutaminase 1 (K polypeptide epidermal type I, protein-glutamine-gamma-glutamyltransferase) |
| Symbol | TGM1 |
| Synonyms | ARCI1; ICR2; KTG; LI; LI1; TGASE; TGK |
| Accession | NM_000359 |
| Cytogenetic | 14q11.2 |
| Amino Acid Labeled | [U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys |
| Chemical Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Expression Host | Human HEK293 cells |
| Predicted MW | 89.6 kDa |
| Expression TrueORF Clone | RC204492 |
| Description | TGM1 Full-Length MS Protein Standard (NP_000350), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is a membrane protein that catalyzes the addition of an alkyl group from an akylamine to a glutamine residue of a protein, forming an alkylglutamine in the protein. This protein alkylation leads to crosslinking of proteins and catenation of polyamines to proteins. This gene contains either one or two copies of a 22 nt repeat unit in its 3 UTR. Mutations in this gene have been associated with autosomal recessive lamellar ichthyosis (LI) and nonbullous congenital ichthyosiform erythroderma (NCIE). |
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