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ARNTL Full-Length MS Protein Standard

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Product Description


NameARNTL Full-Length MS Protein Standard
Cat#CPFL304464
Protein Namearyl hydrocarbon receptor nuclear translocator-like
SymbolARNTL
SynonymsbHLHe5; BMAL1; BMAL1c; JAP3; MOP3; PASD3; TIC
AccessionNM_001030273
Cytogenetic11p15
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionARNTL Full-Length MS Protein Standard (NP_001025444), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene.

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