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C12orf5 Full-Length MS Protein Standard

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Product Description


NameC12orf5 Full-Length MS Protein Standard
Cat#CPFL304087
Protein Namechromosome 12 open reading frame 5
SymbolC12orf5
SynonymsFR2BP; TIGAR
AccessionNM_020375
Cytogenetic12p13.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionC12orf5 Full-Length MS Protein Standard (NP_065108), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region.

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