XRCC6 Full-Length MS Protein Standard
Product Description:
| Name |
XRCC6 Full-Length MS Protein Standard |
| Cat# |
CPFL304048 |
| Protein Name | X-ray repair complementing defective repair in Chinese hamster cells 6 |
| Symbol | XRCC6 |
| Synonyms | CTC75; CTCBF; G22P1; KU70; ML8; TLAA |
| Accession | NM_001469 |
| Cytogenetic | 22q13.2 |
| Amino Acid Labeled | [U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys |
| Chemical Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Expression Host | Human HEK293 cells |
| Predicted MW | 69.7 kDa |
| Expression TrueORF Clone | RC204048 |
| Description | XRCC6 Full-Length MS Protein Standard (NP_001460), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The p70/p80 autoantigen is a nuclear complex consisting of two subunits with molecular masses of approximately 70 and 80 kDa. The complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. High levels of autoantibodies to p70 and p80 have been found in some patients with systemic lupus erythematosus. |
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