HMGCL Full-Length MS Protein Standard


Product Description:

Name HMGCL Full-Length MS Protein Standard
Cat# CPFL303817
Protein Name3-hydroxymethyl-3-methylglutaryl-CoA lyase
SymbolHMGCL
SynonymsHL
AccessionNM_000191
Cytogenetic1p36.1-p35
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW31.5 kDa
Expression TrueORF CloneRC203817
DescriptionHMGCL Full-Length MS Protein Standard (NP_000182), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene belongs to the HMG-CoA lyase family. It is a mitochondrial enzyme that catalyzes the final step of leucine degradation and plays a key role in ketone body formation. Mutations in this gene are associated with HMG-CoA lyase deficiency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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