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ALOX5AP Full-Length MS Protein Standard

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Product Description


NameALOX5AP Full-Length MS Protein Standard
Cat#CPFL303785
Protein Namearachidonate 5-lipoxygenase-activating protein
SymbolALOX5AP
SynonymsFLAP
AccessionNM_001629
Cytogenetic13q12
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionALOX5AP Full-Length MS Protein Standard (NP_001620), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.

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