LTA Full-Length MS Protein Standard


Product Description:

Name LTA Full-Length MS Protein Standard
Cat# CPFL303741
Protein Namelymphotoxin alpha (TNF superfamily, member 1)
SymbolLTA
SynonymsLT; TNFB; TNFSF1
AccessionNM_000595
Cytogenetic6p21.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW18.6 kDa
Expression TrueORF CloneRC203741
DescriptionLTA Full-Length MS Protein Standard (NP_000586), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4, myocardial infarction, non-Hodgkins lymphoma, and psoriatic arthritis. Alternatively spliced transcript variants have been observed for this gene.

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