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DHCR24 Full-Length MS Protein Standard

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Product Description


NameDHCR24 Full-Length MS Protein Standard
Cat#CPFL303507
Protein Name24-dehydrocholesterol reductase
SymbolDHCR24
SynonymsDCE; Nbla03646; seladin-1; SELADIN1
AccessionNM_014762
Cytogenetic1p32.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionDHCR24 Full-Length MS Protein Standard (NP_055577), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.

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