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ATIC Full-Length MS Protein Standard

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Product Description


NameATIC Full-Length MS Protein Standard
Cat#CPFL303490
Protein Name5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
SymbolATIC
SynonymsAICAR; AICARFT; HEL-S-70p; IMPCHASE; PURH
AccessionNM_004044
Cytogenetic2q35
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionATIC Full-Length MS Protein Standard (NP_004035), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a bifunctional protein that catalyzes the last two steps of the de novo purine biosynthetic pathway. The N-terminal domain has phosphoribosylaminoimidazolecarboxamide formyltransferase activity, and the C-terminal domain has IMP cyclohydrolase activity. A mutation in this gene results in AICA-ribosiduria.

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