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RNF34 Full-Length MS Protein Standard

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Product Description


NameRNF34 Full-Length MS Protein Standard
Cat#CPFL303191
Protein Namering finger protein 34, E3 ubiquitin protein ligase
SymbolRNF34
SynonymsCARP-1; CARP1; hRFI; RFI; RIF; RIFF
AccessionNM_025126
Cytogenetic12q24.31
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionRNF34 Full-Length MS Protein Standard (NP_079402), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This protein also targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms.

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