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INS Full-Length MS Protein Standard

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Product Description


NameINS Full-Length MS Protein Standard
Cat#CPFL302701
Protein Nameinsulin
SymbolINS
SynonymsIDDM; IDDM1; IDDM2; ILPR; IRDN; MODY10
AccessionNM_000207
Cytogenetic11p15.5
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionINS Full-Length MS Protein Standard (NP_000198), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5 region and with the IGF2 gene at the 3 region. Alternative splicing results in multiple transcript variants.

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