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NRAS Full-Length MS Protein Standard

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Product Description


NameNRAS Full-Length MS Protein Standard
Cat#CPFL302681
Protein Nameneuroblastoma RAS viral (v-ras) oncogene homolog
SymbolNRAS
SynonymsALPS4; CMNS; N-ras; NCMS; NRAS1; NS6
AccessionNM_002524
Cytogenetic1p13.2
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionNRAS Full-Length MS Protein Standard (NP_002515), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia.

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