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USP5 Full-Length MS Protein Standard

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Product Description


NameUSP5 Full-Length MS Protein Standard
Cat#CPFL302624
Protein Nameubiquitin specific peptidase 5 (isopeptidase T)
SymbolUSP5
SynonymsISOT
AccessionNM_003481
Cytogenetic12p13
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionUSP5 Full-Length MS Protein Standard (NP_003472), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 )

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