OPTN Full-Length MS Protein Standard


Product Description:

Name OPTN Full-Length MS Protein Standard
Cat# CPFL302470
Protein Nameoptineurin
SymbolOPTN
SynonymsALS12; FIP2; GLC1E; HIP7; HYPL; NRP; TFIIIA-INTP
AccessionNM_001008211
Cytogenetic10p13
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW65.7 kDa
Expression TrueORF CloneRC202470
DescriptionOPTN Full-Length MS Protein Standard (NP_001008212), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

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