GM2A Full-Length MS Protein Standard


Product Description:

Name GM2A Full-Length MS Protein Standard
Cat# CPFL302452
Protein NameGM2 ganglioside activator
SymbolGM2A
SynonymsGM2-AP; SAP-3
AccessionNM_000405
Cytogenetic5q33.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW20.7 kDa
Expression TrueORF CloneRC202452
DescriptionGM2A Full-Length MS Protein Standard (NP_000396), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a small glycolipid transport protein which acts as a substrate specific co-factor for the lysosomal enzyme beta-hexosaminidase A. Beta-hexosaminidase A, together with GM2 ganglioside activator, catalyzes the degradation of the ganglioside GM2, and other molecules containing terminal N-acetyl hexosamines. Mutations in this gene result in GM2-gangliosidosis type AB or the AB variant of Tay-Sachs disease. Alternative splicing results in multiple transcript variants.

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