ITM2B Full-Length MS Protein Standard


Product Description:

Name ITM2B Full-Length MS Protein Standard
Cat# CPFL302377
Protein Nameintegral membrane protein 2B
SymbolITM2B
SynonymsABRI; BRI; BRI2; BRICD2B; E25B; E3-16; FBD; imBRI2; RDGCA
AccessionNM_021999
Cytogenetic13q14.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW30.2 kDa
Expression TrueORF CloneRC202377
DescriptionITM2B Full-Length MS Protein Standard (NP_068839), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia.

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