Product Description:

Name	GAPDH Full-Length MS Protein Standard
Cat#	CPFL302309
Protein Name	glyceraldehyde-3-phosphate dehydrogenase
Symbol	GAPDH
Synonyms	G3PD; GAPD; HEL-S-162eP
Accession	NM_002046
Cytogenetic	12p13
Amino Acid Labeled	[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression Host	Human HEK293 cells
Predicted MW	35.9 kDa
Expression TrueORF Clone	RC202309
Description	GAPDH Full-Length MS Protein Standard (NP_002037), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants.

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