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CBFA2T2 Full-Length MS Protein Standard

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Product Description


NameCBFA2T2 Full-Length MS Protein Standard
Cat#CPFL302013
Protein Namecore-binding factor, runt domain, alpha subunit 2; translocated to, 2
SymbolCBFA2T2
SynonymsEHT; MTGR1; p85; ZMYND3
AccessionNM_001039709
Cytogenetic20q11
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionCBFA2T2 Full-Length MS Protein Standard (NP_001034798), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5-region of the RUNX1 (AML1) gene fused to the 3-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described.

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