ERCC5 Full-Length MS Protein Standard


Product Description:

Name ERCC5 Full-Length MS Protein Standard
Cat# CPFL301994
Protein Nameexcision repair cross-complementing rodent repair deficiency, complementation group 5
SymbolERCC5
SynonymsCOFS3; ERCC5-201; ERCM2; UVDR; XPG; XPGC
AccessionNM_000123
Cytogenetic13q33
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW133.1 kDa
Expression TrueORF CloneRC201994
DescriptionERCC5 Full-Length MS Protein Standard (NP_000114), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a single-strand specific DNA endonuclease that makes the 3 incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene.

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