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ASCC1 Full-Length MS Protein Standard

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Product Description


NameASCC1 Full-Length MS Protein Standard
Cat#CPFL301872
Protein Nameactivating signal cointegrator 1 complex subunit 1
SymbolASCC1
SynonymsASC1p50; CGI-18; RP11-150D20.4
AccessionNM_015947
Cytogenetic10pter-q25.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionASCC1 Full-Length MS Protein Standard (NP_057031), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

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