CDKN1A Full-Length MS Protein Standard


Product Description:

Name CDKN1A Full-Length MS Protein Standard
Cat# CPFL301765
Protein Namecyclin-dependent kinase inhibitor 1A (p21, Cip1)
SymbolCDKN1A
SynonymsCAP20; CDKN1; CIP1; MDA-6; P21; p21CIP1; SDI1; WAF1
AccessionNM_078467
Cytogenetic6p21.2
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW17.9 kDa
Expression TrueORF CloneRC201765
DescriptionCDKN1A Full-Length MS Protein Standard (NP_510867), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene.

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