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NME1 Full-Length MS Protein Standard

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Product Description


NameNME1 Full-Length MS Protein Standard
Cat#CPFL301731
Protein NameNME/NM23 nucleoside diphosphate kinase 1
SymbolNME1
SynonymsAWD; GAAD; NB; NBS; NDKA; NDPK-A; NDPKA; NM23; NM23-H1
AccessionNM_000269
Cytogenetic17q21.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionNME1 Full-Length MS Protein Standard (NP_000260), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of A (encoded by this gene) and B (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product.

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