| Name | CRK Full-Length MS Protein Standard |
|---|---|
| Cat# | CPFL301701 |
| Protein Name | v-crk sarcoma virus CT10 oncogene homolog (avian) |
| Symbol | CRK |
| Synonyms | CRKII; p38 |
| Accession | NM_016823 |
| Cytogenetic | 17p13.3 |
| Amino Acid Labeled | [U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys |
| Chemical Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Expression Host | Human HEK293 cells |
| Predicted MW | 33.7 kDa |
| Expression TrueORF Clone | RC201701 |
| Description | CRK Full-Length MS Protein Standard (NP_058431), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. |
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