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RAD18 Full-Length MS Protein Standard

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Product Description


NameRAD18 Full-Length MS Protein Standard
Cat#CPFL301700
Protein NameRAD18 RAD18 homolog (S. cerevisiae)
SymbolRAD18
SynonymsRNF73
AccessionNM_020165
Cytogenetic3p25-p24
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionRAD18 Full-Length MS Protein Standard (NP_064550), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens.

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