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MGMT Full-Length MS Protein Standard

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Product Description


NameMGMT Full-Length MS Protein Standard
Cat#CPFL301612
Protein NameO-6-methylguanine-DNA methyltransferase
SymbolMGMT
SynonymsO6-methylguanine-DNA methyltransferase; OTTHUMP00000020741; methylguanine-DNA methyltransferase; O-6-methylguanine-DNA methyltransferase
AccessionNM_002412
Cytogenetic10q26
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionMGMT Full-Length MS Protein Standard (NP_002403), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.

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