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MLH1 Full-Length MS Protein Standard

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Product Description


NameMLH1 Full-Length MS Protein Standard
Cat#CPFL301607
Protein NamemutL homolog 1
SymbolMLH1
SynonymsCOCA2; FCC2; hMLH1; HNPCC; HNPCC2
AccessionNM_000249
Cytogenetic3p21.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionMLH1 Full-Length MS Protein Standard (NP_000240), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.

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