NAE1 Full-Length MS Protein Standard


Product Description:

Name NAE1 Full-Length MS Protein Standard
Cat# CPFL301326
Protein NameNEDD8 activating enzyme E1 subunit 1
SymbolNAE1
SynonymsA-116A10.1; APPBP1; HPP1; ula-1
AccessionNM_001018160
Cytogenetic16q22
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW50.4 kDa
Expression TrueORF CloneRC201326
DescriptionNAE1 Full-Length MS Protein Standard (NP_001018170), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimers disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.

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