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APEX1 Full-Length MS Protein Standard

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Product Description


NameAPEX1 Full-Length MS Protein Standard
Cat#CPFL301208
Protein NameAPEX nuclease (multifunctional DNA repair enzyme) 1
SymbolAPEX1
SynonymsAPE; APE1; APEN; APEX; APX; HAP1; REF1
AccessionNM_080648
Cytogenetic14q11.2
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionAPEX1 Full-Length MS Protein Standard (NP_542379), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5 to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

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