CDKN2D Full-Length MS Protein Standard


Product Description:

Name CDKN2D Full-Length MS Protein Standard
Cat# CPFL301155
Protein Namecyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
SymbolCDKN2D
SynonymsINK4D; p19; p19-INK4D
AccessionNM_079421
Cytogenetic19p13
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW17.5 kDa
Expression TrueORF CloneRC201155
DescriptionCDKN2D Full-Length MS Protein Standard (NP_524145), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.

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