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KDSR Full-Length MS Protein Standard

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Product Description


NameKDSR Full-Length MS Protein Standard
Cat#CPFL301153
Protein Name3-ketodihydrosphingosine reductase
SymbolKDSR
SynonymsDHSR; FVT1; SDR35C1
AccessionNM_002035
Cytogenetic18q21.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionKDSR Full-Length MS Protein Standard (NP_002026), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy.

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