COPS5 Full-Length MS Protein Standard


Product Description:

Name COPS5 Full-Length MS Protein Standard
Cat# CPFL300979
Protein NameCOP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
SymbolCOPS5
SynonymsCSN5; JAB1; MOV-34; SGN5
AccessionNM_006837
Cytogenetic8q13.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW37.4 kDa
Expression TrueORF CloneRC200979
DescriptionCOPS5 Full-Length MS Protein Standard (NP_006828), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors.

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