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ELAC2 Full-Length MS Protein Standard

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Product Description


NameELAC2 Full-Length MS Protein Standard
Cat#CPFL300764
Protein NameelaC homolog 2 (E. coli)
SymbolELAC2
SynonymsCOXPD17; ELC2; HPC2
AccessionNM_018127
Cytogenetic17p11.2
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionELAC2 Full-Length MS Protein Standard (NP_060597), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene has a C-terminal domain with tRNA 3 processing endoribonuclease activity, which catalyzes the removal of the 3 trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

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