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NFKBIA Full-Length MS Protein Standard

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Product Description


NameNFKBIA Full-Length MS Protein Standard
Cat#CPFL300711
Protein Namenuclear factor of kappa light polypeptide gene enhancer in B-cell extracts inhibitor, alpha
SymbolNFKBIA
SynonymsIKBA; MAD-3; NFKBI
AccessionNM_020529
Cytogenetic14q13
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionNFKBIA Full-Length MS Protein Standard (NP_065390), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

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