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OAS1 Full-Length MS Protein Standard

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Product Description


NameOAS1 Full-Length MS Protein Standard
Cat#CPFL300696
Protein Name2-5-oligoadenylate synthetase 1, 40/46kDa
SymbolOAS1
SynonymsIFI-4; OIAS; OIASI
AccessionNM_002534
Cytogenetic12q24.2
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionOAS1 Full-Length MS Protein Standard (NP_002525), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2-specific nucleotidyl transfer reactions to synthesize 2,5-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Mutations in this gene have been associated with host susceptibility to viral infection. Alternatively spliced transcript variants encoding different isoforms have been described.

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