FKBP1A Full-Length MS Protein Standard


Product Description:

Name FKBP1A Full-Length MS Protein Standard
Cat# CPFL300662
Protein NameFK506 binding protein 1A, 12kDa
SymbolFKBP1A
SynonymsFKBP-12; FKBP-1A; FKBP1; FKBP12; PKC12; PKCI2; PPIASE
AccessionNM_054014
Cytogenetic20p13
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW11.8 kDa
Expression TrueORF CloneRC200662
DescriptionFKBP1A Full-Length MS Protein Standard (NP_463460), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It interacts with several intracellular signal transduction proteins including type I TGF-beta receptor. It also interacts with multiple intracellular calcium release channels, and coordinates multi-protein complex formation of the tetrameric skeletal muscle ryanodine receptor. In mouse, deletion of this homologous gene causes congenital heart disorder known as noncompaction of left ventricular myocardium. Multiple alternatively spliced variants, encoding the same protein, have been identified. The human genome contains five pseudogenes related to this gene, at least one of which is transcribed.

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