NQO1 Full-Length MS Protein Standard


Product Description:

Name NQO1 Full-Length MS Protein Standard
Cat# CPFL300620
Protein NameNAD(P)H dehydrogenase, quinone 1
SymbolNQO1
SynonymsDHQU; DIA4; DTD; NMOR1; NMORI; QR1
AccessionNM_000903
Cytogenetic16q22.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW30.7 kDa
Expression TrueORF CloneRC200620
DescriptionNQO1 Full-Length MS Protein Standard (NP_000894), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This proteins enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimers disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

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