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GMDS Full-Length MS Protein Standard

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Product Description


NameGMDS Full-Length MS Protein Standard
Cat#CPFL300471
Protein NameGDP-mannose 4,6-dehydratase
SymbolGMDS
SynonymsGMD; SDR3E1
AccessionNM_001500
Cytogenetic6p25
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionGMDS Full-Length MS Protein Standard (NP_001491), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. GDP-mannose 4,6-dehydratase (GMD; EC 4.2.1.47) catalyzes the conversion of GDP-mannose to GDP-4-keto-6-deoxymannose, the first step in the synthesis of GDP-fucose from GDP-mannose, using NADP+ as a cofactor. The second and third steps of the pathway are catalyzed by a single enzyme, GDP-keto-6-deoxymannose 3,5-epimerase, 4-reductase, designated FX in humans (MIM 137020).

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