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GRB2 Full-Length MS Protein Standard

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Product Description


NameGRB2 Full-Length MS Protein Standard
Cat#CPFL300469
Protein Namegrowth factor receptor-bound protein 2
SymbolGRB2
SynonymsASH; EGFRBP-GRB2; Grb3-3; MST084; MSTP084; NCKAP2
AccessionNM_002086
Cytogenetic17q24-q25
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionGRB2 Full-Length MS Protein Standard (NP_002077), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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