HK1 Full-Length MS Protein Standard


Product Description:

Name HK1 Full-Length MS Protein Standard
Cat# CPFL300464
Protein NameHexokinase 1
SymbolHK1
SynonymsHK1-ta; HK1-tb; HK1-tc; HKD; HKI; HMSNR; HXK1
AccessionNM_000188
Cytogenetic10q22
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW102.3 kDa
Expression TrueORF CloneRC200464
DescriptionHK1 Full-Length MS Protein Standard (NP_000179), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein.

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