OGDH Full-Length MS Protein Standard


Product Description:

Name OGDH Full-Length MS Protein Standard
Cat# CPFL300446
Protein Nameoxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)
SymbolOGDH
SynonymsAKGDH; E1k; OGDC
AccessionNM_002541
Cytogenetic7p14-p13
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW111.3 kDa
Expression TrueORF CloneRC200446
DescriptionOGDH Full-Length MS Protein Standard (NP_002532), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

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