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BAP1 Full-Length MS Protein Standard

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Product Description


NameBAP1 Full-Length MS Protein Standard
Cat#CPFL300378
Protein NameBRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
SymbolBAP1
SynonymsHUCEP-13; hucep-6; UCHL2
AccessionNM_004656
Cytogenetic3p21.31-p21.2
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionBAP1 Full-Length MS Protein Standard (NP_004647), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma.

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