EIF2S1 Full-Length MS Protein Standard


Product Description:

Name EIF2S1 Full-Length MS Protein Standard
Cat# CPFL300368
Protein Nameeukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
SymbolEIF2S1
SynonymsEIF-2; EIF-2A; EIF-2alpha; EIF2; EIF2A
AccessionNM_004094
Cytogenetic14q23.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW35.9 kDa
Expression TrueORF CloneRC200368
DescriptionEIF2S1 Full-Length MS Protein Standard (NP_004085), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 )

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