PCMT1 Full-Length MS Protein Standard


Product Description:

Name PCMT1 Full-Length MS Protein Standard
Cat# CPFL300327
Protein Nameprotein-L-isoaspartate (D-aspartate) O-methyltransferase
SymbolPCMT1
SynonymsPIMT
AccessionNM_005389
Cytogenetic6q25.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW30.1 kDa
Expression TrueORF CloneRC200327
DescriptionPCMT1 Full-Length MS Protein Standard (NP_005380), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the type II class of protein carboxyl methyltransferase enzymes. The encoded enzyme plays a role in protein repair by recognizing and converting D-aspartyl and L-isoaspartyl residues resulting from spontaneous deamidation back to the normal L-aspartyl form. The encoded protein may play a protective role in the pathogenesis of Alzheimers disease, and single nucleotide polymorphisms in this gene have been associated with spina bifida and premature ovarian failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

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