TGM2 Full-Length MS Protein Standard


Product Description:

Name TGM2 Full-Length MS Protein Standard
Cat# CPFL300226
Protein Nametransglutaminase 2
SymbolTGM2
SynonymsG-ALPHA-h; GNAH; HEL-S-45; TG2; TGC
AccessionNM_198951
Cytogenetic20q12
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW61.5 kDa
Expression TrueORF CloneRC200226
DescriptionTGM2 Full-Length MS Protein Standard (NP_945189), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene.

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