AKR1C3 Full-Length MS Protein Standard


Product Description:

Name AKR1C3 Full-Length MS Protein Standard
Cat# CPFL300210
Protein Namealdo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
SymbolAKR1C3
SynonymsDD3; DDX; HA1753; HAKRB; HAKRe; hluPGFS; HSD17B5; PGFS
AccessionNM_003739
Cytogenetic10p15-p14
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW36.7 kDa
Expression TrueORF CloneRC200210
DescriptionAKR1C3 Full-Length MS Protein Standard (NP_003730), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.

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