TTK Full-Length MS Protein Standard


Product Description:

Name TTK Full-Length MS Protein Standard
Cat# CPFL300093
Protein NameTTK protein kinase
SymbolTTK
SynonymsCT96; ESK; MPH1; MPS1; MPS1L1; PYT
AccessionNM_003318
Cytogenetic6q14.1
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
Chemical Purity> 80% as determined by SDS-PAGE and Coomassie blue staining
Expression HostHuman HEK293 cells
Predicted MW96.9 kDa
Expression TrueORF CloneRC200093
DescriptionTTK Full-Length MS Protein Standard (NP_003309), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a dual specificity protein kinase with the ability to phosphorylate tyrosine, serine and threonine. Associated with cell proliferation, this protein is essential for chromosome alignment at the centromere during mitosis and is required for centrosome duplication. It has been found to be a critical mitotic checkpoint protein for accurate segregation of chromosomes during mitosis. Tumorigenesis may occur when this protein fails to degrade and produces excess centrosomes resulting in aberrant mitotic spindles. Alternative splicing results in multiple transcript variants.

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