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ITGB3BP Full-Length MS Protein Standard

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Product Description


NameITGB3BP Full-Length MS Protein Standard
Cat#CPFL300064
Protein Nameintegrin beta 3 binding protein (beta3-endonexin)
SymbolITGB3BP
SynonymsCENP-R; CENPR; HSU37139; NRIF3; TAP20
AccessionNM_014288
Cytogenetic1p31.3
Amino Acid Labeled[U- 13C6, 15N4]-L-Arg and [U- 13C6, 15N2]-L-Lys
DescriptionITGB3BP Full-Length MS Protein Standard (NP_055103), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics. This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signaling. This protein induces apoptosis in breast cancer cells through a caspase 2-mediated signaling pathway. This protein is also a component of the centromere-specific histone H3 variant nucleosome associated complex (CENP-NAC) and may be involved in mitotic progression by recruiting the histone H3 variant CENP-A to the centromere. Alternate splicing results in multiple transcript variants.

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