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Macrolides Residue Testing Service

The residues of macrolides may endanger the health of consumers. Creative Proteomics provides you with qualitative and quantitative detection of macrolides residues in food. We can customize different detection schemes according to different detection purposes.  

The basic structure of macrolide antibiotics (MALs) has a highly substituted macrolide ring. MALs have high inhibitory activity against gram-positive bacteria and mycoplasma, and are widely used in the treatment of various infectious diseases in food-producing animals. MALs can also be added to animal feed as growth promoters, which may lead to excessive use of MALs.

Macrolides Residue Testing Service

MALs easily accumulate in animals. Its side effects have been found in the clinic. Common side effects include gastrointestinal reactions, allergic reactions, severe cochlear nerve damage, hearing loss, liver and kidney damage, and drug resistance.

Macrolide antibiotics are mainly metabolized by the liver, through cytochrome P450 biotransformation or other metabolic methods, to produce physiologically active metabolites or inactive metabolites. In addition to the detection of original drugs, the detection of MALs metabolites also needs to be taken seriously. Many metabolites of macrolide drugs retain their active groups and have antibacterial spectrum and antibacterial activity similar to the original drug.

Overuse or unreasonable application of MALs may put consumers at risk. Many countries have also established maximum residue limits for MALs. In order to protect the health of consumers and comply with food import and export inspections, Creative Proteomics has developed a rapid detection platform suitable for the analysis of macrolides residues for manufacturers, enterprises, and government organizations. We strictly abide by the quality assurance/quality control plans and regulatory requirements of each country and region to provide you with support. Including but not limited to the following standards and methods: ISO, FDA, EU regulations.

Macrolides Residue Testing Service in Creative Proteomics

Based on our rich experience, Creative Proteomics provides you with a professional platform to analyze macrolides. We can provide the following macrolides, including but not limited to:

     MACROLIDES CAN BE ANALYZED AT CREATIVE PROTEOMICS
1Spiramycin8Azithromycin
2Tilmicosin9Erythromycin
3Oleandomycin10Roxithromycin
4Erythromycin11Clarithromycin
5Tylosin12Medicin
6Kitasamycin13Josamycin
7Lincomycin14 

Food Macrolides Residue Testing Platform

Sample preparation method:

  • QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) method
  • Solid-phase extraction

Sample detection technology:

  • Enzyme-linked immunoassay (ELISA): This method can only be used for screening, not as a confirmation method.
  • Reversed-phase high performance liquid chromatography: detection limit is 0.016-0.041mg/kg, quantification limit is 0.053-0.135 mg/kg.
  • Liquid chromatography-electrospray mass spectrometry (LC / ESI-MS / MS): Data acquisition under MS / MS is achieved by multi-reaction monitoring (MRM) of two or three fragment ion transitions. It is more sensitive than liquid chromatography. The detection limit is less than 1.0μg/kg, and the quantification limit is 0.005-0.030mg/kg.

Turnaround Time: 7-10 working days.

Acceptable Samples: Poultry, red meat, offal, shellfish, fish, eggs, honey and milk.

At Creative Proteomics, our analytical scientists are experienced in macrolides residue testing. After communicating with you about the testing scheme, we will implement it within a quick turnaround time and provide you with an analysis report. If you have any questions or specific needs, do not hesitate to contact us.

* Not intended for personal food safety testing.

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