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Antihistamines Residue Testing Service

The residues of Antihistamines may endanger the health of consumers. Creative Proteomics provides you with qualitative and quantitative detection of antihistamines residues in food. We can customize different detection schemes according to different detection purposes.  

Antihistamines can be used for anti-emesis, anti-dizziness, motion sickness and sedation and hypnosis. They have a wide range of pharmacological effects in veterinary clinic. The addition of such drugs in the feed can stimulate the feeding center. Therefore, the use of these drugs in the animal breeding process can achieve the effects of increasing animal feeding and promoting growth and weight gain. In addition, the use of antihistamines can reduce the mortality of animals during transportation. As a result, illegal or inappropriate use of such drugs still occurs.

Antihistamines Residue Testing Service

Antihistamines are highly fat-soluble and easily accumulate in adipose tissue. The metabolites can still be detected in urine several weeks or even half a year after drug withdrawal, and some metabolites still have drug activity. For example, chlorpromazine, promethazine and other drugs are metabolized by the liver and oxidized to sulfoxide structure under the catalysis of cytochrome P450 enzyme, which will cause leukopenia and agranulocytosis, thereby causing liver and kidney lesions and eye complications. Therefore, the use of antihistamine drugs in the aquaculture industry has been restricted in many countries and regions such as the United States and the European Union.

In order to protect the health of consumers and ensure that your products meet the statutory requirements of various countries and regions, Creative Proteomics has developed a technology platform for simultaneous determination of multiple antihistamines and their metabolite residues. We strictly abide by the quality assurance/quality control plans and regulatory requirements of each country and region to provide you with support. Including but not limited to the following standards and methods: ISO, FDA, EU regulations.

Antihistamines Residue Testing Service in Creative Proteomics

Based on our rich experience, Creative Proteomics provides you with a professional platform to analyze antihistamines. We can provide the following antihistamines, including but not limited to:

     ANTIHISTAMINES CAN BE TESTED AT CREATIVE PROTEOMICS
1Astemizole11Diphenhydramine
2Terfenadine12Chlorpromazine
3Cetirizine13Chlorpromazine sulfoxide
4Loratadine14Promethazin
5Hydroxyzine15Promethazine sulfoxide
6Brompheniramine16Fluphenazine
7Deloratadine17Fluphenazine sulfoxide
8Cyproheptadine18Perphenazine
9Chlorpheniramine19Perphenazine sulfoxide
10Triprenamin  

Food Antihistamines Residue Testing Platform

Sample preparation method:

  • QuEChERS (Quick, Easy, Cheap, Effective, Rugged, and Safe) method
  • Solid-phase extraction (SPE)

Sample detection technology:

  • Gas chromatography-mass spectrometry (GC-MS)
  • Liquid chromatography-electrospray mass spectrometry (LC / ESI-MS / MS): 
  • Ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS / MS)

* No need for derivatization. Strong qualitative ability. High sensitivity and selectivity.

Turnaround Time: 7-10 working days.

Acceptable Samples: All foods of animal origin.

At Creative Proteomics, our analytical scientists are experienced in antihistamines residue testing. After communicating with you about the testing scheme, we will implement it within a quick turnaround time and provide you with an analysis report. If you have any questions or specific needs, do not hesitate to contact us.

* Not intended for personal food safety testing.

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